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genitalium infections, but access to testing for M. NAATs are the only feasible, sensitive and specific diagnostic methods for M. If not detected and appropriately treated, these infections may result in pelvic inflammatory disease (PID), preterm birth, spontaneous miscarriage, and tubal factor infertility. genitalium causes urethritis in males, and urethritis and cervicitis in females. However, the clinical importance of these species is disputed, particularly when they are confined to the lower urogenital tract. There are many other human-associated Mycoplasma species, including M. genitalium coding sequences have orthologues in M. pneumoniae which has a larger genome size of 816 kbp compared to the smaller genome of only 580 kbp for the M. It is closely related to the important respiratory tract pathogen M.
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Mycoplasma genitalium is a pathogenic member of the Mycoplasmataceae restricted to humans, primarily colonizing the urogenital tract, and causing sexually transmitted infections in both males and female. It represents a first approach to its population genetics to better appreciate the role of this organism as a sexually transmitted pathogen. The sequence data here generated is essential for designing rational approaches to type and track Mycoplasma genitalium as antibiotic resistance increases. SNPs found in region V of 23S rRNA and parC were consistent with azithromycin/erythromycin and fluoroquinolone resistances, respectively, and with their phenotypic MIC data. Using these data, we generated a robust phylogeny which shows that there are two main clades with differing degrees of genomic variability. These regions include the MgPar loci, associated with host interactions, as well as other genes that could also be involved in this role. However, we identified extensive recombination across their genomes with a total of 25 regions showing heightened levels of SNP density. All the strain showed essentially the same genomic content without any accessory regions found.
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We sequenced 28 genomes of Mycoplasma genitalium from temporally (1980–2010) and geographically (Europe, Japan, Australia) diverse sources. genitalium has developed resistance to mainly all therapeutic antimicrobials. This is set against a background of drug resistance whereby M. genitalium relies on molecular tests targeting specific genes or regions of the genome and knowledge is limited by a general under-testing internationally. Currently our understanding of the nature and diversity of M. Hence, we lack a robust phylogenetic framework to provide insights into the population structure of the species. Although Mycoplasma genitalium is a common sexually transmitted pathogen causing clinically distinct diseases both in male and females, few genomes have been sequenced up to now, due mainly to its fastidious nature and slow growth.